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In DSS-induced and TNBS-induced colitis models, oral KPV significantly reduced disease severity, colonic inflammation, and pro-inflammatory cytokine expression

The pathogenesis involves a breakdown of self-tolerance, enhanced antigen presentation, T and B lymphocyte activation, autoantibody production, and cytokine-mediated thyroid tissue damage

Epub 2014 Oct 3 Giunta C, Baumann M, Fauth C, Lindert U, Abdalla EM, Brady AF, Collins J, Dastgir J, Donkervoort S, Ghali N, Johnson DS, Kariminejad A, Koch J, Kraenzlin M, Lahiri N, Lozic B, Manzur AY, Morton JEV, Pilch J, Pollitt RC, Schreiber G, Shannon NL, Sobey G, Vandersteen A, van Dijk FS, Witsch-Baumgartner M, Zschocke J, Pope FM, Bnnemann CG, Rohrbach M